OR1N2

OR1N2 is a gene that encodes the olfactory receptor, family 1, subfamily N, member 2 protein in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The OR1N2 gene is part of the olfactory receptor gene family, which is the largest gene family in the human genome. The proteins encoded by these genes are responsible for the recognition and transduction of odorant signals, which are mediated by G proteins. This gene family is highly polymorphic and diverse, with each gene encoding a unique receptor that can recognize a specific odorant molecule.

Structure

The OR1N2 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2, from base pair 156,104,297 to base pair 156,105,487. The gene is composed of a single coding exon. The protein encoded by this gene shares a 7-transmembrane domain structure with many neurotransmitter and hormone receptors.

Clinical Significance

While the specific clinical significance of OR1N2 is not yet fully understood, the olfactory receptor gene family as a whole has been implicated in a variety of diseases, including anosmia (loss of the sense of smell), and olfactory neuroblastoma (a rare type of cancer that starts in the olfactory nerve).

File:OR1N2 gene location on human chromosome 1.png

Location of the OR1N2 gene on human chromosome 1.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Olfactory neuroblastoma

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