OR2A5

OR2A5 is a gene that encodes a protein in the olfactory receptor family. The olfactory receptor family is the largest in the genome. The family members are G-protein coupled receptors that respond to odor molecules and are responsible for the sense of smell. The OR2A5 gene is specifically expressed in the olfactory epithelium, which is a specialized tissue inside the nose that is involved in smell.

Structure

The OR2A5 gene is located on chromosome 7 and spans approximately 3 kilobases. The gene contains one exon and encodes a protein of 312 amino acids. The protein has seven transmembrane domains, a characteristic feature of G-protein coupled receptors. The protein also contains a large extracellular loop, which is thought to be involved in odorant binding.

Function

The OR2A5 protein is a member of the olfactory receptor family, which is responsible for the detection of odor molecules. The protein is expressed in the olfactory epithelium, where it is thought to bind to odor molecules and initiate a neural response that results in the perception of smell. The exact odorant that the OR2A5 protein responds to is currently unknown.

Clinical significance

Mutations in the OR2A5 gene have been associated with a reduced sense of smell, a condition known as anosmia. In addition, variations in the OR2A5 gene have been linked to a heightened sensitivity to certain odors. However, more research is needed to fully understand the clinical significance of the OR2A5 gene.

See also

• Olfactory receptor
• Anosmia
• G-protein coupled receptor