OR2AP1

OR2AP1 is a gene that encodes a protein in humans. It is also known as olfactory receptor, family 2, subfamily AP, member 1. This gene is part of the olfactory receptor gene family, which is the largest gene family in the genome. The olfactory receptors are G protein-coupled receptors that are involved in the detection of odorants.

Function

The OR2AP1 gene is a member of the olfactory receptor family of genes. These genes are expressed in the olfactory epithelium of the nose and are responsible for the detection of odorants. The proteins they encode, known as olfactory receptors, are located on the cilia of olfactory sensory neurons. When an odorant molecule binds to an olfactory receptor, it triggers a signal transduction pathway that results in a nerve impulse being sent to the brain.

Structure

The OR2AP1 gene is located on chromosome 11, specifically on the long (q) arm of the chromosome at position 11.2. The gene spans approximately 1,000 base pairs. The encoded protein is a member of the G protein-coupled receptor 1 family. Like all G protein-coupled receptors, it has seven transmembrane domains.

Clinical significance

Mutations in the OR2AP1 gene have not been directly linked to any human diseases. However, the olfactory system, of which this gene is a part, plays a crucial role in several neurological disorders, including Parkinson's disease and Alzheimer's disease. Research is ongoing to determine the exact role of olfactory receptors in these conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• Parkinson's disease
• Alzheimer's disease

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