OR2B3

OR2B3 is a gene that encodes the olfactory receptor protein 2B3 in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Structure

The OR2B3 gene is located on chromosome 17, specifically on the long (q) arm at position 11.2. The exact location is from base pair 28,031,805 to base pair 28,032,896. The gene spans approximately 1.1 kilobases and consists of a single coding exon. The encoded protein, OR2B3, is composed of 312 amino acids and has a predicted molecular weight of approximately 35 kDa.

Function

The primary function of OR2B3 is to recognize and transduce odorant signals. This is achieved through the binding of specific odorant molecules to the receptor, which triggers a cascade of intracellular events leading to the generation of a nerve impulse that is transmitted to the brain. This process is essential for the sense of smell.

Clinical Significance

While the exact role of OR2B3 in disease is not well understood, variations in olfactory receptor genes, including OR2B3, have been associated with differences in smell perception. This includes both general olfactory sensitivity as well as specific anosmias, or the inability to smell certain odors. Further research is needed to elucidate the potential role of OR2B3 in disease.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia