OR2C3

OR2C3 is a gene that encodes the olfactory receptor 2C3 in humans. The olfactory receptor family is the largest in the genome. The olfactory receptors (ORs) are G protein-coupled receptors (GPCRs) that play a role in the detection of odor molecules.

Function

The OR2C3 gene is a member of the olfactory receptor family of genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Structure

The OR2C3 gene is located on chromosome 1, specifically on the long (q) arm of chromosome 1 at position 44. The exact location is from base pair 240,769,522 to base pair 240,770,623. The gene spans about 1.1 kilobases. The encoded protein, OR2C3, is 310 amino acids long.

Clinical significance

Mutations in the OR2C3 gene have been associated with a decreased sense of smell, or anosmia. Further research is needed to fully understand the implications of these mutations.

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor