OR2F2

OR2F2 is a gene that encodes a protein in humans. It is also known as olfactory receptor, family 2, subfamily F, member 2. The OR2F2 gene is part of the olfactory receptor gene family, which is the largest gene family in the genome. The family members are G-protein coupled receptors that respond to smell and taste stimuli and are divided into a large number of subfamilies.

Function

The OR2F2 gene provides instructions for making a protein that is involved in the detection of odors. The protein, also known as an olfactory receptor, is located in specialized sensory cells within the nose called olfactory receptor neurons. These cells connect directly to the brain.

Structure

The OR2F2 gene is located on the short (p) arm of chromosome 11 at position 15.4. More precisely, the OR2F2 gene is located from base pair 3,000,000 to base pair 3,100,000 on chromosome 11.

Clinical significance

Mutations in the OR2F2 gene can lead to a reduced ability to smell, a condition known as anosmia. However, because the sense of smell is mediated by a large number of different olfactory receptors, the loss of function of a single receptor typically does not lead to a complete loss of smell.

See also

• Olfactory receptor
• Chromosome 11
• Anosmia

References

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