OR2G3

OR2G3 is a gene that encodes a protein in humans. This protein is a member of the olfactory receptor family, a class of G protein-coupled receptors (GPCRs) that are involved in the detection of smell. The OR2G3 gene is located on chromosome 1, specifically at 1q44.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific role of OR2G3 in disease is not well understood, olfactory receptors in general have been implicated in a variety of conditions. For example, mutations in olfactory receptors have been associated with anosmia, a condition characterized by a loss of the sense of smell. Additionally, some studies have suggested that olfactory receptors may play a role in diseases such as cancer and neurodegenerative diseases.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Cancer
• Neurodegenerative diseases