OR2L13

OR2L13 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor Family 2 Subfamily L Member 13. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR2L13 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases. The gene is expressed in several tissues, including the olfactory epithelium.

Clinical Significance

While the specific clinical significance of OR2L13 is not yet fully understood, olfactory receptors in general have been linked to various diseases. For example, mutations in olfactory receptors have been associated with anosmia, a condition characterized by a loss of the sense of smell.

See Also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

References

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