OR2T27

OR2T27 is a gene that encodes a protein in humans. This protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell. The olfactory receptor proteins interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Gene

The OR2T27 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases and consists of a single exon. The gene is expressed in the olfactory epithelium, a specialized tissue in the nose that is involved in smell.

Protein

The OR2T27 protein is a member of the olfactory receptor family, which is the largest family of G protein-coupled receptors. The protein is composed of 312 amino acids and has a molecular weight of approximately 35 kilodaltons. It is predicted to have seven transmembrane domains, a characteristic feature of G protein-coupled receptors.

Clinical significance

While the exact role of OR2T27 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including Parkinson's disease, Alzheimer's disease, and certain types of cancer. Further research is needed to determine the specific role of OR2T27 in these and other conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• 1q44 deletion syndrome

References

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