OR2T33

OR2T33 is a gene that encodes a protein in humans. This protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell. The OR2T33 gene is located on chromosome 1, specifically at 1q44.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical Significance

While the specific function and clinical significance of OR2T33 are not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, mutations in olfactory receptor genes have been associated with anosmia, the inability to perceive smell. Additionally, some olfactory receptors have been found to be ectopically expressed in a number of cancers.

Research

Research into the OR2T33 gene and its encoded protein is ongoing, with scientists seeking to better understand its function and potential role in disease. This research could potentially lead to new diagnostic methods or treatments for conditions related to the olfactory system.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia