OR2W3

OR2W3 is a gene that encodes the olfactory receptor protein 2W3 in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Structure

The OR2W3 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2, from base pair 150,726,214 to base pair 150,727,214. The gene is composed of 1 exon. The OR2W3 protein encoded by this gene belongs to the family A of GPCRs, specifically OR2 (olfactory receptor, family 2).

Function

The OR2W3 protein is an olfactory receptor, a type of protein that plays a role in the sense of smell. These receptors, located in the nasal cavity, detect odor molecules in the air and send signals to the brain regarding the smell. Each olfactory receptor protein interacts with specific odor molecules, contributing to the ability to recognize and distinguish different smells.

Clinical Significance

While the specific clinical significance of OR2W3 is not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, mutations in olfactory receptor genes have been associated with a decreased sense of smell (anosmia). Further research is needed to determine the specific role of OR2W3 in human health and disease.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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