OR4M2

OR4M2 is a gene that encodes a protein in humans. It is also known as olfactory receptor, family 4, subfamily M, member 2. This gene is part of the olfactory receptor gene family, which is the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The OR4M2 gene is a member of the olfactory receptor family, which is responsible for our sense of smell. This family is the largest in the genome, with several hundred genes expressed in a combinatorial manner. Each olfactory receptor gene encodes a unique protein that can recognize a specific odor molecule. When an odor molecule binds to an olfactory receptor, it triggers a signal transduction pathway that leads to the perception of the smell.

Structure

The OR4M2 gene is located on chromosome 14q11.1 and spans approximately 1 kilobase. The gene contains one exon and encodes a protein of 312 amino acids. The protein has seven transmembrane domains, a characteristic feature of G-protein coupled receptors. The N-terminus of the protein is located outside the cell, while the C-terminus is inside the cell.

Clinical Significance

While the exact role of OR4M2 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including Parkinson's disease, Alzheimer's disease, and certain types of cancer. Further research is needed to determine the specific role of OR4M2 in these and other conditions.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Signal transduction