OR51B4

OR51B4 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odor molecules and the transduction of odorant signals. The OR51B4 gene is specifically expressed in the olfactory epithelium, a specialized tissue in the nose involved in smell.

Structure

The OR51B4 gene is located on chromosome 11 in humans. It spans approximately 1 kilobase and consists of a single exon. The encoded protein is a member of the G protein-coupled receptor superfamily, which is characterized by seven transmembrane domains. The protein is 312 amino acids in length.

Function

The OR51B4 protein is an olfactory receptor, which is a type of G protein-coupled receptor. Olfactory receptors detect odor molecules in the nose and initiate a neural response that triggers the perception of a smell. The OR51B4 receptor is believed to have a broad ligand spectrum, meaning it can bind to and detect a wide range of odor molecules.

Clinical significance

Mutations in the OR51B4 gene have been associated with a reduced sense of smell, a condition known as anosmia. In addition, some studies have suggested that variations in this gene may influence individual differences in smell perception.

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

References

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