OR52J3

OR52J3 is a gene that encodes a protein in humans. This gene is also known as olfactory receptor family 52 subfamily J member 3. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

The OR52J3 gene is part of the olfactory receptor gene family, which is the largest in the genome. The olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR52J3 gene is located on chromosome 11 (11p15.4). It spans about 1,000 base pairs of DNA and consists of a single coding exon. The gene is expressed in the olfactory epithelium.

Protein

The protein encoded by the OR52J3 gene is a member of the olfactory receptor family of G-protein-coupled receptors. It is specifically expressed in the olfactory epithelium and is thought to play a role in odorant recognition.

Clinical significance

While the specific function and clinical significance of OR52J3 are not yet fully understood, olfactory receptors in general are known to play a role in a wide range of physiological and pathological processes. Mutations in olfactory receptor genes have been linked to various diseases, including congenital anosmia (inability to smell).

See also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 11

References

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