OR52K2

OR52K2 is a gene that encodes a protein in humans. This protein is part of the olfactory receptor family, a group of proteins that are involved in the detection of smell. The OR52K2 gene is located on chromosome 11.

Function

The protein encoded by the OR52K2 gene is an olfactory receptor. Olfactory receptors are part of the G protein-coupled receptor superfamily. They are located in the cell membranes of olfactory receptor neurons in the olfactory epithelium, the part of the nose responsible for detecting smells. These receptors interact with odorant molecules in the air, triggering a neuronal response that is transmitted to the brain.

Structure

The OR52K2 protein is a transmembrane protein, meaning it spans the membrane of the olfactory receptor neurons. Like all olfactory receptors, it has seven transmembrane domains. These domains form a pocket in the cell membrane where odorant molecules can bind.

Clinical significance

While the exact role of OR52K2 in human health and disease is not fully understood, olfactory receptors in general are thought to play a role in various diseases and conditions. For example, changes in the sense of smell can be an early sign of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. More research is needed to understand the specific role of OR52K2 in these and other conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• Olfactory epithelium