OR5AR1

OR5AR1 is a gene that encodes a protein in the olfactory receptor family. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific function of OR5AR1 is not yet fully understood, it is believed to play a role in the complex process of olfaction. Mutations in this gene, as well as other olfactory receptor genes, could potentially play a role in disorders of the sense of smell (anosmia).

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor

External links

• OR5AR1 at NCBI