OR5AT1

OR5AT1 is a gene that encodes a protein in humans. The protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR5AT1 gene is located on the chromosome 11 (11q11). It spans a length of about 1.1 kb. The gene is encoded by a single exon.

Protein

The OR5AT1 protein is a member of the olfactory receptor family. It is a G protein-coupled receptor and is involved in the detection of smell. The protein is 312 amino acids long, with a molecular weight of approximately 35 kDa.

Clinical significance

While the exact role of OR5AT1 in human health and disease is not fully understood, olfactory receptors such as OR5AT1 are thought to have roles in various physiological and pathological processes. These include sperm chemotaxis, the regulation of appetite, and the detection of environmental hazards. Mutations in olfactory receptor genes, including OR5AT1, have been associated with various diseases, although the specific diseases associated with OR5AT1 are not known.

See also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 11

References

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