OR5I1

OR5I1 is a gene that encodes a protein in humans. This protein is part of the olfactory receptor family, a group of proteins that are involved in the detection of smell. The OR5I1 gene is located on chromosome 11.

Function

The protein encoded by the OR5I1 gene is an olfactory receptor. Olfactory receptors are part of the G protein-coupled receptor superfamily. They are located in the cell membranes of olfactory receptor neurons in the olfactory epithelium, the part of the nose responsible for detecting smells. These receptors interact with odorant molecules in the air, triggering a neuronal response that is transmitted to the brain.

Structure

The OR5I1 protein is a transmembrane protein, meaning it spans the membrane of the olfactory receptor neurons. Like all olfactory receptors, it has seven transmembrane domains. These domains form a pocket where odorant molecules can bind, triggering a change in the shape of the protein and initiating a signal transduction pathway.

Clinical significance

While the exact role of the OR5I1 gene in human health and disease is not fully understood, it is thought to play a role in our sense of smell. Mutations in this gene could potentially lead to a reduced ability to smell, a condition known as anosmia. However, more research is needed to confirm this.

See also

• Olfactory receptor
• Anosmia
• G protein-coupled receptor
• Signal transduction

References

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