OR5M3

OR5M3 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor Family 5 Subfamily M Member 3. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR5M3 gene is located on chromosome 1, specifically at 1q44. It spans a length of about 1.1 kilobases. The gene is expressed in the olfactory epithelium, a specialized tissue in the nose that is involved in smell.

Protein

The protein encoded by the OR5M3 gene is a member of the olfactory receptor family. It is a G-protein coupled receptor that is involved in the detection of smell. The protein is composed of 312 amino acids and has a molecular weight of approximately 35 kilodaltons.

Clinical significance

While the exact role of OR5M3 in disease is not well understood, olfactory receptors in general have been implicated in a variety of diseases, including Parkinson's disease, Alzheimer's disease, and certain types of cancer. Further research is needed to determine the specific role of OR5M3 in these and other conditions.

See also

• Olfactory receptor
• G protein-coupled receptor
• 1q44 deletion syndrome

References

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