OR5R1

OR5R1 is a gene that encodes a protein in humans. This protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell. The OR5R1 gene is located on chromosome 1, specifically at 1q44.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific function and clinical significance of OR5R1 are not yet fully understood, olfactory receptors in general play a crucial role in the sense of smell. Mutations in these receptors can lead to a variety of conditions, including anosmia (the inability to perceive odor), and hyposmia (a reduced ability to smell and to detect odors).

Research

Research into the OR5R1 gene and its associated protein is ongoing. Understanding the function and structure of this gene could provide insights into the olfactory system and potential treatments for conditions affecting the sense of smell.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Hyposmia

References

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