OR5T1

OR5T1 is a gene that encodes a protein in humans. This protein is a member of the olfactory receptor family, which is involved in the detection of smell. The olfactory receptor proteins are G protein-coupled receptors (GPCRs) that detect odor molecules in the nose and initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific function of OR5T1 is not well understood, mutations in olfactory receptor genes, including OR5T1, have been associated with various diseases and conditions. For example, a decreased sense of smell (anosmia) can be caused by mutations in olfactory receptor genes. Additionally, some studies suggest that variations in olfactory receptor genes may be associated with a predisposition to certain types of cancer.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Cancer

External links

• OR5T1 at NCBI
• OR5T1 at GeneCards