OR6A2

OR6A2 is a gene that encodes the olfactory receptor protein 6A2. This protein is a member of the olfactory receptor family, a group of proteins that are responsible for detecting odorant molecules and transmitting signals to the brain. The OR6A2 receptor is particularly sensitive to the compound aldehyde C-9, which is found in many foods and is responsible for the characteristic smell of coriander.

Structure

The OR6A2 gene is located on chromosome 11 in humans. It spans approximately 3 kilobases and consists of a single exon. The encoded protein is a G protein-coupled receptor that contains seven transmembrane domains, a characteristic feature of this protein family.

Function

The primary function of OR6A2 is to detect odorant molecules and initiate a neural signal that is transmitted to the brain. This process begins when an odorant molecule binds to the receptor, causing a conformational change that activates the associated G protein. This in turn triggers a series of intracellular events that ultimately result in the generation of a neural signal.

OR6A2 has a high affinity for aldehyde C-9, a compound that is found in many foods and is responsible for the characteristic smell of coriander. Some individuals carry a variant of the OR6A2 gene that makes them highly sensitive to this compound, causing them to perceive coriander as having a soapy or unpleasant taste.

Clinical significance

Variations in the OR6A2 gene have been associated with differences in individuals' perception of certain smells and tastes. For example, a common variant of this gene is associated with a dislike of coriander, a common herb used in many cuisines. This has potential implications for dietary preferences and nutrition.

See also

• Olfactory receptor
• G protein-coupled receptor
• Aldehyde C-9
• Coriander