OR6T1

OR6T1 is a gene that encodes the olfactory receptor, family 6, subfamily T, member 1. It is part of the olfactory receptor family of genes which are the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Clinical significance

While the specific function of OR6T1 is not fully understood, it is believed to play a role in the complex process of detecting and distinguishing odors. Mutations in this gene have been associated with a reduction in the ability to smell (anosmia). Further research is needed to fully understand the implications of this gene in human health and disease.

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

External links

• OR6T1 at the National Center for Biotechnology Information