OR8J3

OR8J3 is a gene that encodes the olfactory receptor, family 8, subfamily J, member 3 in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The protein encoded by the OR8J3 gene is an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes.

Gene

The OR8J3 gene is located on the chromosome 11 (11p15.4). It spans 1,093 base pairs and encodes a protein of 317 amino acids. The gene is expressed in the olfactory epithelium.

Clinical Significance

While the specific clinical significance of OR8J3 is not yet fully understood, olfactory receptors in general are being studied for their potential roles in disease. For example, changes in the sense of smell can be an early sign of Parkinson's disease or Alzheimer's disease.

See Also

• Olfactory receptor
• G-protein coupled receptors
• Chromosome 11