ORG-26576
ORG-26576 is an amplakine compound that was developed by Organon International in collaboration with Pierre Fabre Medicament. It acts as a positive allosteric modulator of the AMPA receptor, which is a type of ionotropic glutamate receptor involved in fast synaptic transmission in the central nervous system.
History[edit | edit source]
ORG-26576 was first synthesized by Organon International and Pierre Fabre Medicament. The compound was developed as part of a research program aimed at discovering new treatments for neurological disorders and psychiatric disorders.
Mechanism of Action[edit | edit source]
ORG-26576 works by enhancing the activity of the AMPA receptor. This receptor is a type of ionotropic glutamate receptor that plays a crucial role in fast synaptic transmission in the central nervous system. By modulating the activity of this receptor, ORG-26576 can potentially improve cognitive function and treat various neurological and psychiatric disorders.
Clinical Trials[edit | edit source]
ORG-26576 has undergone Phase I and Phase II clinical trials. The Phase I trial demonstrated that the compound was well-tolerated in healthy volunteers. The Phase II trial, which was conducted in patients with major depressive disorder, showed that ORG-26576 had a beneficial effect on depressive symptoms. However, further research is needed to confirm these findings and to fully understand the therapeutic potential of this compound.
See Also[edit | edit source]
- Amplakine
- Organon International
- Pierre Fabre Medicament
- AMPA receptor
- Ionotropic glutamate receptor
- Central nervous system
- Neurological disorders
- Psychiatric disorders
- Major depressive disorder
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