Oct-2
Octamer-binding transcription factor 2 | |
---|---|
Identifiers | |
Symbol | OCT2 |
HGNC | 7874 |
OMIM | 164175 |
Other data | |
Locus | Chr. 19 q13.2 |
Octamer-binding transcription factor 2 (OCT2), also known as POU domain, class 2, transcription factor 2 (POU2F2), is a protein that in humans is encoded by the POU2F2 gene. OCT2 is a member of the POU family of transcription factors, which play critical roles in cell differentiation and the maintenance of specific cellular identities.
Function[edit | edit source]
OCT2 is involved in the regulation of gene expression in B lymphocytes, a type of white blood cell crucial for the immune system. It binds to the octamer motif (5'-ATTTGCAT-3'), which is a regulatory element in the promoters of the genes involved in immune response and cell cycle regulation. This transcription factor is essential for the proper development of B cells and their response to antigens.
Structure[edit | edit source]
The structure of OCT2 includes a POU-specific domain and a POU homeodomain. These domains are involved in the DNA-binding activity of the protein and contribute to its specificity and regulatory functions.
Clinical Significance[edit | edit source]
Alterations in the expression of OCT2 can be associated with certain types of cancer, such as lymphoma and leukemia. Its role in B cell development and function also implicates it in autoimmune diseases, where immune cells target and damage the body's own tissues.
Research[edit | edit source]
Research on OCT2 has focused on its role in immune regulation and its potential as a target for therapeutic interventions in diseases involving B cells. Studies have also explored its interactions with other transcription factors and the mechanisms by which it influences gene expression and cellular differentiation.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD