Oct-2

From WikiMD's Wellness Encyclopedia

Octamer-binding transcription factor 2
Identifiers
SymbolOCT2
HGNC7874
OMIM164175
Other data
LocusChr. 19 q13.2


Octamer-binding transcription factor 2 (OCT2), also known as POU domain, class 2, transcription factor 2 (POU2F2), is a protein that in humans is encoded by the POU2F2 gene. OCT2 is a member of the POU family of transcription factors, which play critical roles in cell differentiation and the maintenance of specific cellular identities.

Function[edit | edit source]

OCT2 is involved in the regulation of gene expression in B lymphocytes, a type of white blood cell crucial for the immune system. It binds to the octamer motif (5'-ATTTGCAT-3'), which is a regulatory element in the promoters of the genes involved in immune response and cell cycle regulation. This transcription factor is essential for the proper development of B cells and their response to antigens.

Structure[edit | edit source]

The structure of OCT2 includes a POU-specific domain and a POU homeodomain. These domains are involved in the DNA-binding activity of the protein and contribute to its specificity and regulatory functions.

Clinical Significance[edit | edit source]

Alterations in the expression of OCT2 can be associated with certain types of cancer, such as lymphoma and leukemia. Its role in B cell development and function also implicates it in autoimmune diseases, where immune cells target and damage the body's own tissues.

Research[edit | edit source]

Research on OCT2 has focused on its role in immune regulation and its potential as a target for therapeutic interventions in diseases involving B cells. Studies have also explored its interactions with other transcription factors and the mechanisms by which it influences gene expression and cellular differentiation.

See Also[edit | edit source]


Contributors: Prab R. Tumpati, MD