Oligopeptide P11-4

Oligopetide P11-4

Oligopeptide P11-4 is a synthetic peptide that has garnered attention in the field of dentistry and biomaterials for its potential applications in dental caries prevention and tooth remineralization. This peptide is designed to self-assemble into a fibrillar scaffold under specific conditions, which can then facilitate the remineralization of enamel.

Structure and Properties

Oligopeptide P11-4 is composed of a sequence of amino acids that enable it to form a three-dimensional scaffold. The peptide sequence is specifically engineered to respond to changes in pH, which is a critical factor in the oral environment. When exposed to the acidic conditions typically found in carious lesions, P11-4 undergoes a conformational change that allows it to self-assemble into a fibrillar network.

Mechanism of Action

The primary mechanism by which Oligopeptide P11-4 functions involves its ability to create a scaffold that mimics the natural extracellular matrix of enamel. This scaffold provides a framework for the deposition of calcium and phosphate ions, which are essential for the remineralization process. The peptide's self-assembling properties are triggered by the acidic pH found in early carious lesions, making it a targeted approach for dental caries management.

Applications in Dentistry

Oligopeptide P11-4 has shown promise in several dental applications, particularly in the prevention and treatment of early-stage dental caries. By promoting the natural remineralization process, it offers a non-invasive alternative to traditional restorative treatments. Clinical studies have demonstrated its efficacy in reducing carious lesions and enhancing enamel hardness.

Research and Development

Research on Oligopeptide P11-4 is ongoing, with studies focusing on its long-term effectiveness, optimal application methods, and potential uses in other areas of biomaterials and tissue engineering. The peptide's ability to self-assemble and promote mineral deposition makes it a versatile tool in the development of new dental treatments.

Related Pages

• Dentistry
• Dental caries
• Tooth remineralization
• Enamel
• Calcium
• Phosphate
• Biomaterials
• Tissue engineering