Olpadronic acid

Olpadronic acid

Olpadronic acid is a bisphosphonate, a class of drugs that prevent the loss of bone density. It is used for the treatment of osteoporosis, a condition that weakens bones and makes them prone to fracture. Olpadronic acid works by inhibiting the activity of osteoclasts, the cells that break down bone, thereby increasing bone density and strength.

Chemistry

Olpadronic acid, also known as alendronic acid, is a nitrogen-containing bisphosphonate. Its chemical formula is C4H13NO7P2. It is a white, crystalline powder that is soluble in water. The drug is administered orally, usually as a tablet.

Pharmacology

Olpadronic acid works by binding to hydroxyapatite in bone tissue, which inhibits the activity of osteoclasts. This reduces bone resorption and turnover, leading to an increase in bone mineral density. The drug is absorbed in the upper gastrointestinal tract and is excreted unchanged in the urine.

Clinical use

Olpadronic acid is used for the treatment of osteoporosis in postmenopausal women. It is also used to prevent and treat osteoporosis in men and women who are taking corticosteroids, which can cause bone loss. In addition, the drug is used to treat Paget's disease of bone, a condition that causes abnormal bone remodeling.

Side effects

Common side effects of olpadronic acid include gastrointestinal problems such as heartburn, nausea, and diarrhea. Less common side effects include bone, joint, or muscle pain, and rare but serious side effects include jawbone problems and unusual fractures of the thigh bone.

See also

• Bisphosphonate
• Osteoporosis
• Paget's disease of bone