Omega-3-acid ethyl esters

Omega-3-acid ethyl esters are a group of polyunsaturated fatty acids that are used as a dietary supplement and medication to lower triglyceride levels and improve overall cardiovascular health. These compounds are derived from fish oil and include eicosapentaenoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DHA), which are the ethyl ester forms of omega-3 fatty acids. Omega-3-acid ethyl esters are often prescribed to individuals who have high triglyceride levels, a risk factor for atherosclerosis and cardiovascular disease.

Medical Uses

Omega-3-acid ethyl esters are primarily used to reduce high triglyceride levels in the blood, which is a risk factor for atherosclerosis and heart disease. They are also used in conjunction with diet and exercise to improve lipid profiles and cardiovascular health. The American Heart Association recommends the use of omega-3 fatty acids for individuals with documented coronary heart disease.

Mechanism of Action

The exact mechanism by which omega-3-acid ethyl esters reduce triglyceride levels is not fully understood. However, it is believed that they work by inhibiting the synthesis of triglycerides in the liver, as EPA and DHA can reduce the enzyme activity that produces triglycerides. Additionally, omega-3 fatty acids may improve cardiovascular health by reducing inflammation and blood clotting, improving endothelial function, and lowering blood pressure.

Side Effects

Common side effects of omega-3-acid ethyl esters include indigestion, nausea, and a fishy aftertaste. Less common but more serious side effects may include increased risk of bleeding, immune system suppression, and high blood sugar levels. Patients are advised to consult with a healthcare provider before starting any new supplement, especially if they are taking other medications or have underlying health conditions.

Pharmacology

Omega-3-acid ethyl esters are absorbed through the gastrointestinal tract and metabolized primarily in the liver. The pharmacokinetics of these agents may vary depending on individual factors such as age, liver function, and the presence of other medical conditions.

Interactions

Omega-3-acid ethyl esters can interact with anticoagulant and antiplatelet medications, increasing the risk of bleeding. They may also interact with other medications that affect blood lipid levels. Patients should inform their healthcare provider of all medications and supplements they are taking to avoid potential interactions.

See Also

• Eicosapentaenoic acid
• Docosahexaenoic acid
• Cardiovascular disease
• Hypertriglyceridemia