Opioid growth factor
Opioid Growth Factor (OGF), also known as [Met5]-enkephalin, is a naturally occurring peptide that has been found to inhibit the growth of cancer cells and other cells. It is an endogenous opioid peptide that interacts with the opioid growth factor receptor (OGFr) to regulate cell proliferation and tissue organization.
Structure and Function[edit | edit source]
OGF is a small peptide composed of five amino acids: tyrosine, glycine, glycine, phenylalanine, and methionine. It is produced in various tissues throughout the body, including the brain, adrenal glands, and immune cells.
The primary function of OGF is to regulate cell proliferation. It does this by binding to the OGFr, which is found on the surface of many different types of cells. This binding triggers a series of biochemical reactions that ultimately lead to a decrease in cell proliferation.
In addition to its role in regulating cell growth, OGF also has been found to have analgesic properties, meaning it can help to relieve pain. This is thought to be due to its ability to bind to opioid receptors in the brain.
Clinical Significance[edit | edit source]
Because of its ability to inhibit cell growth, OGF has been studied as a potential treatment for cancer. Research has shown that OGF can inhibit the growth of a variety of different types of cancer cells, including those from lung, breast, and colon cancers.
In addition to its potential use in cancer treatment, OGF also has been investigated for its potential use in the treatment of other conditions that involve abnormal cell growth, such as psoriasis and rheumatoid arthritis.
See Also[edit | edit source]
References[edit | edit source]
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