Ornipressin

Ornipressin is a vasopressin analogue, specifically a synthetic variant of arginine vasopressin, used in medicine for its vasoconstrictive properties. It is primarily used in the management of esophageal varices, a condition often associated with cirrhosis of the liver.

Pharmacology

Ornipressin acts on vasopressin receptors, specifically the V1 receptor subtype, to induce vasoconstriction. This action is useful in conditions where reducing blood flow is beneficial, such as in the management of esophageal varices. The drug is administered intravenously and has a rapid onset of action.

Clinical Use

The primary use of ornipressin in medicine is in the management of esophageal varices, particularly in the context of cirrhosis. By inducing vasoconstriction, ornipressin reduces blood flow to the varices, reducing the risk of rupture and subsequent hemorrhage. It may also be used in other conditions where vasoconstriction is beneficial, although these uses are less common.

Side Effects

Like all medications, ornipressin can cause side effects. These may include hypertension, bradycardia, and ischemia due to its vasoconstrictive properties. It may also cause water retention and hyponatremia due to its action on vasopressin receptors.

Contraindications

Ornipressin should not be used in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe cardiovascular disease due to the risk of exacerbating these conditions.

See Also

• Vasopressin
• Esophageal varices
• Cirrhosis