Ovarian clear-cell carcinoma

Ovarian clear-cell carcinoma (OCCC) is a type of ovarian cancer that is characterized by clear cells and is often resistant to chemotherapy. It is a rare subtype of epithelial ovarian cancer, accounting for approximately 5-25% of all ovarian cancer cases.

Epidemiology

OCCC is more common in women of Asian descent, particularly those from Japan. The average age of diagnosis is in the mid-50s.

Pathogenesis

The exact cause of OCCC is unknown, but it is thought to be associated with endometriosis, a condition in which tissue similar to the lining of the uterus grows outside of the uterus.

Clinical Presentation

Symptoms of OCCC can be non-specific and may include abdominal pain, bloating, and changes in urinary or bowel habits.

Diagnosis

Diagnosis of OCCC is typically made through a combination of imaging studies, such as ultrasound or computed tomography (CT) scans, and tissue biopsy.

Treatment

Treatment for OCCC typically involves surgery to remove the tumor, followed by chemotherapy. However, OCCC is often resistant to traditional chemotherapy drugs, making treatment more challenging.

Prognosis

The prognosis for OCCC is generally poorer than for other types of ovarian cancer, due in part to its resistance to chemotherapy.

See Also

• Ovarian cancer
• Endometriosis
• Chemotherapy

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