Oxalosuccinic acid
Oxalosuccinic acid is an intermediate compound in the citric acid cycle, also known as the Krebs cycle or the tricarboxylic acid cycle. It is formed from isocitrate via the enzyme isocitrate dehydrogenase, and is subsequently converted into alpha-ketoglutarate.
Structure and Properties[edit | edit source]
Oxalosuccinic acid is a dicarboxylic acid with the chemical formula C4H4O7. It contains two carboxyl groups (-COOH) and one keto group (=O). The molecule is highly polar due to the presence of these functional groups, and it is therefore soluble in water.
Role in the Citric Acid Cycle[edit | edit source]
In the citric acid cycle, oxalosuccinic acid plays a crucial role in the conversion of isocitrate to alpha-ketoglutarate. This reaction is catalyzed by the enzyme isocitrate dehydrogenase, which removes a hydrogen atom from isocitrate and adds a carbonyl group to form oxalosuccinic acid. The oxalosuccinic acid is then decarboxylated to form alpha-ketoglutarate, releasing a molecule of carbon dioxide in the process.
Clinical Significance[edit | edit source]
Abnormalities in the metabolism of oxalosuccinic acid can lead to various health conditions. For example, a deficiency in isocitrate dehydrogenase can lead to an accumulation of isocitrate and a decrease in the levels of alpha-ketoglutarate and other downstream metabolites, potentially leading to metabolic acidosis and other metabolic disorders.
See Also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD