Oxetacaine

Oxetacaine (also known as Oxethazaine) is a potent local anesthetic used primarily in the management of gastrointestinal conditions. It is a surface anesthetic, meaning it numbs the surface of the tissues where it is applied, providing relief from pain and discomfort.

Pharmacology

Oxetacaine is a quaternary ammonium compound, which means it carries a positive charge. This allows it to bind to the negatively charged cell membranes of nerve cells, blocking the transmission of nerve impulses and providing local anesthesia.

The drug is poorly absorbed from the gastrointestinal tract, which makes it ideal for use in conditions such as gastritis, peptic ulcer disease, and esophagitis. It is often combined with other drugs, such as antacids, to enhance its therapeutic effect.

Side Effects

Like all medications, Oxetacaine can cause side effects. These are generally mild and may include nausea, vomiting, and allergic reactions. In rare cases, it can cause systemic effects such as hypotension (low blood pressure) and bradycardia (slow heart rate).

Contraindications

Oxetacaine should not be used in patients with known hypersensitivity to the drug or any of its components. It should also be used with caution in patients with severe liver or kidney disease, as these conditions can affect the metabolism and excretion of the drug.

See Also

• Local anesthetic
• Gastrointestinal tract
• Quaternary ammonium compound