Oxolinic acid
An article about the antibiotic oxolinic acid
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Oxolinic acid is a quinolone antibiotic that is used primarily in veterinary medicine. It is a synthetic chemotherapeutic agent that belongs to the class of naphthyridones, which are structurally related to the quinolones. Oxolinic acid is known for its ability to inhibit bacterial DNA gyrase, an enzyme critical for DNA replication in bacteria.
Mechanism of Action[edit | edit source]
Oxolinic acid functions by targeting the bacterial DNA gyrase, an enzyme that introduces negative supercoils into DNA. This process is essential for DNA replication and transcription. By inhibiting DNA gyrase, oxolinic acid prevents the replication of bacterial DNA, thereby exerting its bactericidal effects.
Uses[edit | edit source]
Oxolinic acid is primarily used in veterinary medicine to treat infections caused by Gram-negative bacteria. It is effective against a variety of bacterial species, including those that cause urinary tract infections and gastrointestinal infections in animals.
Pharmacokinetics[edit | edit source]
After administration, oxolinic acid is absorbed and distributed throughout the body. It is metabolized in the liver and excreted primarily through the kidneys. The pharmacokinetic properties of oxolinic acid can vary depending on the species being treated.
Side Effects[edit | edit source]
Like other antibiotics, oxolinic acid can cause side effects. Common side effects include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. In some cases, allergic reactions may occur.
Resistance[edit | edit source]
Bacterial resistance to oxolinic acid can develop through mutations in the genes encoding DNA gyrase. This resistance can limit the effectiveness of the drug and is a concern in both human and veterinary medicine.
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Contributors: Prab R. Tumpati, MD
