Oxolinic acid

Oxolinic acid is a type of quinolone antibiotic, specifically a fluoroquinolone, used in the treatment of urinary tract infections and gastroenteritis. It was first synthesized in Japan in the 1970s and has since been used worldwide.

History

Oxolinic acid was first synthesized in 1970 by the Japanese company Daiichi Sankyo. It was one of the first fluoroquinolones to be developed and has been used in the treatment of bacterial infections for over 50 years.

Medical uses

Oxolinic acid is primarily used in the treatment of urinary tract infections and gastroenteritis. It works by inhibiting the DNA gyrase enzyme, which is necessary for bacterial DNA replication. By inhibiting this enzyme, oxolinic acid prevents the bacteria from replicating and spreading, allowing the body's immune system to eliminate the infection.

Side effects

Like all antibiotics, oxolinic acid can cause side effects. The most common side effects include nausea, vomiting, diarrhea, and abdominal pain. In rare cases, it can cause more serious side effects such as photosensitivity, allergic reactions, and neurological disorders.

Resistance

Bacterial resistance to oxolinic acid has been reported. Resistance occurs when bacteria mutate in a way that makes them immune to the effects of the antibiotic. This can occur through the overuse or misuse of antibiotics.

See also

• Quinolone
• Fluoroquinolone
• Urinary tract infection
• Gastroenteritis