Oxpheneridine

Oxpheneridine

Oxpheneridine is a synthetic opioid analgesic drug, which is a derivative of phenoperidine. It was developed in the 1960s and is used in medicine for the treatment of severe pain.

Chemistry

Oxpheneridine is a phenylpiperidine derivative, which is structurally related to the opioid analgesic drug phenoperidine. It is synthesized by the alkylation of 4-phenylpiperidine with 2-bromoethylbenzene followed by acylation with propionic anhydride.

Pharmacology

Oxpheneridine acts as a potent agonist at the mu-opioid receptor, which is the primary target for most opioid analgesic drugs. It has a high affinity for this receptor and produces a strong analgesic effect. Oxpheneridine also has some affinity for the kappa-opioid receptor and the delta-opioid receptor, but its effects at these receptors are less well understood.

Clinical use

Oxpheneridine is used in medicine for the treatment of severe pain. It is typically administered by injection, and its effects can last for several hours. Oxpheneridine is not commonly used in the United States, but it is used in some other countries, including Russia and China.

Side effects

Like other opioid analgesic drugs, oxpheneridine can cause a range of side effects. These can include drowsiness, nausea, constipation, and respiratory depression. Oxpheneridine can also cause physical dependence and withdrawal symptoms if it is used for a long period of time.

See also

• Opioid
• Analgesic
• Phenoperidine