P2RX6

P2RX6 is a protein that in humans is encoded by the P2RX6 gene. It is a member of the P2X receptor family, which are ATP-gated ion channels and mediate rapid and selective permeability to cations.

Function

The product of this gene, P2RX6, belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is essential for normal pain perception and nociception.

Structure

P2RX6 is a trimeric ion channel that opens in response to the binding of extracellular ATP. Each subunit of the trimer comprises two transmembrane domains, with both the N- and C-terminus located intracellularly. The receptor is almost exclusively located in the plasma membrane.

Clinical significance

Alterations in the P2RX6 gene have been associated with a range of pathological conditions, including chronic pain conditions, inflammatory diseases, and possibly also neurodegenerative diseases. However, the precise role of P2RX6 in these conditions remains to be fully elucidated.

See also

• P2X receptor
• ATP-gated ion channel
• Nociception

External links

• P2RX6 at the US National Library of Medicine Medical Subject Headings (MeSH)