PABPC5

PABPC5 (Poly(A) Binding Protein Cytoplasmic 5) is a protein that in humans is encoded by the PABPC5 gene. It is a member of the poly(A)-binding protein family, which plays a key role in polyadenylation and the control of mRNA stability.

Function

PABPC5 is a cytoplasmic poly(A) binding protein that binds to the poly(A) tail of mRNA, thereby playing a role in post-transcriptional regulation of gene expression. It is involved in various processes such as translation initiation, cap-independent translation, mRNA stabilization and mRNA decay.

Structure

The PABPC5 protein consists of four RNA recognition motifs (RRMs) and a C-terminal domain. The RRMs are responsible for binding to the poly(A) tail of mRNA, while the C-terminal domain interacts with various other proteins involved in mRNA metabolism.

Clinical Significance

Alterations in the expression of PABPC5 have been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Further research is needed to fully understand the role of PABPC5 in these conditions.

See Also

• Poly(A)-binding protein
• Polyadenylation
• mRNA decay

External Links

• PABPC5 at NCBI Gene
• PABPC5 at UniProt