PAM16
PAM16 (also known as Presequence Translocase-Associated Motor 16 Homolog) is a protein that in humans is encoded by the PAM16 gene. It is a component of the mitochondrial protein import machinery, specifically the translocase of the inner mitochondrial membrane (TIM) complex.
Function[edit | edit source]
PAM16 is a part of the presequence translocase-associated motor (PAM) complex, which is essential for protein import into the mitochondria. The PAM complex aids in the translocation of proteins across the mitochondrial inner membrane by coupling ATP hydrolysis to protein translocation. PAM16 and PAM18 form a stable subcomplex within PAM, and their interaction is crucial for the stability and function of the PAM complex.
Clinical Significance[edit | edit source]
Mutations in the PAM16 gene have been associated with various genetic disorders, including mitochondrial diseases. These diseases are a group of metabolic disorders that result from defects in mitochondrial function, primarily affecting the nervous system and muscular system.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
