PARP inhibitor

PARP inhibitors are a group of pharmacological inhibitors of the enzyme poly ADP ribose polymerase (PARP). They are used in the management of certain types of cancer, particularly ovarian cancer and breast cancer.

Mechanism of action

PARP inhibitors work by blocking the action of PARP, an enzyme that is involved in DNA repair. By inhibiting this enzyme, DNA damage in cancer cells accumulates, leading to cell death. This is particularly effective in cancers with mutations in the BRCA1 or BRCA2 genes, which are also involved in DNA repair.

Uses

PARP inhibitors are used in the treatment of certain types of cancer, including:

• Ovarian cancer
• Breast cancer
• Prostate cancer
• Pancreatic cancer

Side effects

Like all medications, PARP inhibitors can cause side effects. These may include:

• Nausea
• Fatigue
• Anemia
• Neutropenia
• Thrombocytopenia

Examples

There are several PARP inhibitors that are currently approved for use, including:

• Olaparib
• Rucaparib
• Niraparib
• Talazoparib

See also

• Chemotherapy
• Targeted therapy
• BRCA mutation

References

PARP inhibitor Resources
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