PCDH1

From WikiMD's Wellness Encyclopedia

PCDH1 or Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene. This gene is a member of the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a chromosome region containing other members of the protocadherin family. The function of this protein is not yet known.

Function[edit | edit source]

Protocadherin-1 is a member of the cadherin superfamily. Cadherins are a type of protein found in the cell membrane and are responsible for cell adhesion. They play a crucial role in maintaining the structure and function of tissues and organs. Protocadherin-1, like other members of the protocadherin family, is thought to play a role in the establishment and function of specific cell-cell connections in the brain.

Clinical significance[edit | edit source]

Mutations in the PCDH1 gene have been associated with asthma susceptibility. Studies have shown that variations in this gene may increase the risk of developing asthma, particularly in people who are exposed to environmental factors such as tobacco smoke.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

  • PCDH1 at the National Center for Biotechnology Information
PCDH1 Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD