Protocadherin

Protocadherin is a group of proteins that are part of the larger cadherin superfamily. They are primarily expressed in the nervous system and play a crucial role in the establishment and function of specific cell-cell connections in the brain.

Function

Protocadherins are involved in maintaining the specificity of synapses, the junctions where nerve cells communicate with each other. They are thought to be involved in a variety of biological processes, including cell adhesion, signal transduction, and the formation of the nervous system during development.

Structure

Protocadherins are characterized by their unique structure, which includes a large extracellular domain, a single transmembrane domain, and a small cytoplasmic domain. The extracellular domain is responsible for mediating cell-cell adhesion, while the cytoplasmic domain interacts with intracellular signaling pathways.

Classification

Protocadherins are classified into three main subfamilies: alpha protocadherins, beta protocadherins, and gamma protocadherins. Each subfamily is further divided into individual isoforms, which are expressed in a highly regulated and tissue-specific manner.

Clinical significance

Mutations in protocadherin genes have been associated with a variety of neurological disorders, including autism, schizophrenia, and intellectual disability. Research is ongoing to further understand the role of protocadherins in these conditions and to develop potential therapeutic strategies.

See also

• Cadherin
• Cell adhesion
• Synapse

References

Protocadherin Resources
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