PD-200,347

PD-200,347 is a synthetic compound that acts as a selective antagonist of the α1-adrenergic receptor subtypes. It is primarily used in research settings to study the physiological and pharmacological roles of these receptors in various tissues.

Chemical Structure and Properties

PD-200,347 is a chemical compound with the molecular formula C19H21N3O2. It belongs to the class of organic compounds known as phenethylamines, which are characterized by a phenethylamine backbone. The compound is specifically designed to interact with adrenergic receptors, which are a class of G protein-coupled receptors (GPCRs) that are targets for catecholamines like norepinephrine and epinephrine.

Mechanism of Action

PD-200,347 functions as an antagonist at the α1-adrenergic receptor subtypes, which include α1A, α1B, and α1D. By binding to these receptors, PD-200,347 inhibits the action of endogenous catecholamines, thereby blocking the physiological responses typically mediated by these receptors. This makes it a valuable tool for dissecting the roles of α1-adrenergic receptors in various biological processes.

Research Applications

PD-200,347 is used extensively in pharmacological research to:

• Investigate the role of α1-adrenergic receptors in cardiovascular function, including their involvement in regulating blood pressure and vascular tone.
• Study the effects of α1-adrenergic receptor blockade in the central nervous system, particularly in relation to stress and anxiety responses.
• Explore the potential therapeutic applications of α1-adrenergic receptor antagonists in conditions such as benign prostatic hyperplasia and hypertension.

Pharmacokinetics

The pharmacokinetic profile of PD-200,347, including its absorption, distribution, metabolism, and excretion, is primarily characterized in preclinical studies. These studies help determine the compound's bioavailability and duration of action, which are critical for its use in experimental settings.

Safety and Toxicology

As with many research chemicals, the safety and toxicological profile of PD-200,347 is not fully established in humans. It is primarily used in controlled laboratory environments, and researchers must adhere to safety guidelines to minimize potential risks.

Also see

• Adrenergic receptor
• α1-adrenergic receptor
• G protein-coupled receptor
• Pharmacology
• Phenethylamine