PDE1

PDE1‏‎ or Phosphodiesterase 1 is a member of the phosphodiesterase family of enzymes that play a crucial role in cellular signal transduction. These enzymes are responsible for the hydrolysis of cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), into their respective monophosphates.

Function[edit | edit source]

PDE1 has a high affinity for both cAMP and cGMP, and its activity is regulated by calcium/calmodulin. It is involved in various physiological processes, including muscle contraction, neuronal signaling, and cell proliferation.

Isoforms[edit | edit source]

There are three known isoforms of PDE1: PDE1A, PDE1B, and PDE1C. These isoforms are encoded by different genes and have distinct tissue distributions and regulatory properties.

Clinical significance[edit | edit source]

Alterations in PDE1 activity have been implicated in various pathological conditions, such as cardiovascular diseases, neurodegenerative diseases, and cancer. Therefore, PDE1 inhibitors are being explored as potential therapeutic agents for these diseases.

References[edit | edit source]

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