PDE10A

Malamas's PDE10A inhibitor number 96 (2011) in tube model

PDE10A (Phosphodiesterase 10A) is an enzyme that belongs to the phosphodiesterase family. It is encoded by the PDE10A gene in humans. This enzyme is involved in the hydrolysis of cyclic nucleotides, specifically cAMP and cGMP, which are important secondary messengers in various signal transduction pathways.

Function

PDE10A plays a crucial role in the regulation of intracellular levels of cyclic nucleotides. By hydrolyzing cAMP and cGMP, PDE10A modulates the signaling pathways that these cyclic nucleotides mediate. This regulation is essential for maintaining cellular homeostasis and proper physiological functions.

Expression

PDE10A is predominantly expressed in the brain, particularly in the striatum, which is a critical region involved in the regulation of movement and cognition. The enzyme's expression in the brain suggests its involvement in neurological processes and potential implications in neuropsychiatric disorders.

Clinical Significance

Alterations in PDE10A activity have been associated with various neurological and psychiatric conditions. For instance, dysregulation of PDE10A has been implicated in schizophrenia, Huntington's disease, and other neurodegenerative disorders. As a result, PDE10A is considered a potential therapeutic target for the treatment of these conditions.

Inhibitors

Several PDE10A inhibitors have been developed for research and potential therapeutic use. These inhibitors aim to modulate the enzyme's activity and thereby influence the cyclic nucleotide signaling pathways. Some of the notable PDE10A inhibitors include papaverine and MP-10.

Related Pages

• Phosphodiesterase
• cAMP
• cGMP
• Striatum
• Schizophrenia
• Huntington's disease