PDE4A

PDE4A is an enzyme that is encoded by the PDE4A gene in humans. It is a member of the phosphodiesterase family of enzymes, which play a crucial role in cellular signaling by breaking down cyclic nucleotides like cyclic AMP (cAMP) and cyclic GMP (cGMP).

Function

PDE4A is a cyclic AMP-specific phosphodiesterase enzyme. Phosphodiesterases (PDEs) are a family of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDE4A, in particular, is important in the brain and other tissues.

Clinical significance

Alterations in the function or expression of PDE4A have been implicated in several disorders, including asthma, schizophrenia, and cardiovascular diseases. Inhibitors of PDE4A, such as rolipram, have been investigated for their therapeutic potential in these and other conditions.

Structure

The PDE4A gene encodes several different isoforms of the enzyme, which are produced through alternative splicing. These isoforms vary in their N-terminal regions, which may influence their subcellular localization and regulatory properties.

See also

• Phosphodiesterase
• PDE4B
• PDE4D