PDGFD

PDGFD (Platelet Derived Growth Factor D) is a protein that in humans is encoded by the PDGFD gene. It is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.

Function

The protein encoded by the PDGFD gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.

Clinical significance

Mutations in PDGFD are associated with malignant tumors. The overexpression of PDGFD has been linked to certain types of cancer, including breast cancer and prostate cancer. It is also involved in several other diseases such as atherosclerosis and liver fibrosis.

See also

• Platelet-derived growth factor
• Gene
• Protein
• Cancer

References

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