PIAS2

PIAS2 is a protein that in humans is encoded by the PIAS2 gene. It is a member of the protein inhibitor of activated STAT (PIAS) family. These proteins function as SUMO E3 ligases and regulate transcriptional activity by modulating the sumoylation status of target proteins.

Function

The PIAS2 protein is a crucial part of the cellular machinery that regulates the activity of various transcription factors. It does this by attaching a small protein called SUMO to these transcription factors, a process known as sumoylation. This modification can alter the function, location, and stability of these proteins, thereby controlling the expression of genes.

Clinical significance

Alterations in the PIAS2 gene have been associated with various diseases. For example, overexpression of PIAS2 has been observed in glioblastoma, the most common and aggressive type of primary brain tumor. In addition, mutations in the PIAS2 gene have been linked to autism spectrum disorder (ASD).

See also

• Protein inhibitor of activated STAT
• SUMO protein
• Transcription factor
• Sumoylation
• Glioblastoma
• Autism spectrum disorder

References

PIAS2 Resources
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