POLG
POLG is a gene that provides instructions for making an enzyme called polymerase (DNA directed), gamma. This enzyme plays a crucial role in the maintenance of mitochondria, the energy-producing centers within cells. The POLG gene is located on the long (q) arm of chromosome 15 at position 26.
Function[edit | edit source]
The POLG enzyme is involved in the replication and repair of mitochondrial DNA. This type of DNA is found in mitochondria and is essential for normal mitochondrial function. The POLG enzyme also helps in the process of mitochondrial DNA replication and mitochondrial DNA repair.
Clinical significance[edit | edit source]
Mutations in the POLG gene have been associated with a variety of disorders, known collectively as POLG-related disorders. These disorders range in severity and can affect many different parts of the body. The most common conditions caused by POLG mutations include progressive external ophthalmoplegia, Alpers-Huttenlocher syndrome, and childhood myocerebrohepatopathy spectrum.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
| POLG Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
