POU4F2

From WikiMD's Wellness Encyclopedia



POU4F2, also known as BRN3B, is a gene that encodes a transcription factor belonging to the POU-IV class. This gene is involved in the regulation of gene expression during neurogenesis and is crucial for the development of the retina.

Function[edit | edit source]

The POU4F2 protein is a transcription factor that binds to specific DNA sequences, thereby controlling the transcription of genetic information from DNA to mRNA. It plays a significant role in the development of retinal ganglion cells and is essential for visual system development.

Clinical Significance[edit | edit source]

Mutations or dysregulation of the POU4F2 gene have been associated with various ocular diseases and neurological disorders. Research indicates that POU4F2 may be involved in the pathogenesis of glaucoma and other retinal degenerative diseases.

Interactions[edit | edit source]

POU4F2 interacts with other transcription factors and co-regulators to modulate the expression of target genes. It is known to interact with POU4F1 and POU4F3, which are also members of the POU-IV class of transcription factors.

Research[edit | edit source]

Studies on POU4F2 have provided insights into its role in neurodevelopment and its potential as a therapeutic target for retinal diseases. Ongoing research is focused on understanding the molecular mechanisms by which POU4F2 regulates gene networks involved in neuronal differentiation and survival.

See Also[edit | edit source]

References[edit | edit source]


External Links[edit | edit source]


{{Navbox | name = Genes on human chromosome 4 | title = Genes on human chromosome 4 | listclass = hlist

| group1 = Locus 4p16.3 | list1 =

| group2 = Locus 4q21-q22 | list2 =

| group3 = Locus 4q25 | list3 =

| group4 = Locus 4q28.3 | list4 =

| group5 = Locus 4q31.21 | list5 =

| group6 = Locus 4q32-q35 | list6 =

| group7 = Other notable genes | list7 =

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Contributors: Prab R. Tumpati, MD